基本信息
李加会，博士，主要从事有机化学、药物化学、化学生物学、生物大分子化学生物学。
Emai: 9906892@haust.edu.cn jiahuilee202309@163.com
教育背景
2018.09-2024.06 南开大学，元素有机化学全国重点实验室，化学生物学专业，理学博士（导师：周传政 教授 国家级领军人才）
2015.09-2018.06 南开大学，元素有机化学全国重点实验室，有机化学专业，理学硕士（导师：周传政 教授 国家级领军人才）
工作履历
2025.12至今 河南科技大学化学化工学院 讲师
研究方向
有机活性分子设计与合成、化学生物学、生物大分子化学机制与应用、核酸和蛋白等生物大分子的合成、修饰及其成药应用。
成果论文
1.Li, Jiahui; Cui, Zenghui; Fan, Chaochao; Zhou, Yifei; Ren, Mengtian; Zhou, Chuanzheng; Photo-caged 2-butene-1,4-dial as an efficient, target-specific photo-crosslinker for covalent trapping of DNA-binding proteins, Chemical Science, 2023, 14: 10884-10891.
2.Li, Jiahui; Wang, Qi; Yin, Mengyuan; Shan, Xiajing; Guan, Wenli; Lu, Kuan; Fan, Chaochao; Zhou, Yifei; Li, Yanjun; Guo, Weiwei; Chen, Quan; Zhou, Chuanzheng; Homobifunctional Photocaged 2-Butene-1,4-dials (bis-PBDAs) as Amino-Reactive Photo-Crosslinkers for Biomaterial Fabrication and Cell Fixation, Chembiochem, 2025, 26: e202500033.
3.Shan, Xiajing; Li, Jiahui Li, Jiahui; Ma, Jingke; Li, Xiaoyao; Liu, Qitong; Zhou, Chuanzheng; Systematic Study of the Impact of DNA Interstrand Cross-Links on Nucleosome Structure, Sliding, and Transcription, Acs Chemical Biology, 2025, 20: 2930-2935.
4.Xiajing Shan; Gaoyuan Ji; Jiahui Li; Mengtian Ren; Jingke Ma; Yifei Zhou; Haitao Li; Chuanzheng Zhou; DNA-histone cross-link locks the nucleosome structure and disrupts its recognition and processing, Protein Cell, 2025, doi: 10.1093/procel/pwaf094.
5.Zang, Chuanlong; Wang, Huawei; Li, Tiantian; Zhang, Yingqian; Li, Jiahui; Shang, Mengdi; Du, Juanjuan; Xi, Zhen; Zhou, Chuanzheng; A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates, Chemical Science, 2019, 10: 8973-8980.
