一、基本信息：
段希焱，博士，教授，硕士生导师，河南科技大学青年骨干教师，主要从事药物化学和有机合成方法学等方面的研究。近年来主持河南省自然科学基金和河南省科技攻关项目，以第一作者或者通讯作者在国际著名期刊European Journal of Medicinal Chemistry，Bioorganic Chemistry，Organic Chemistry Frontiers，Chinese Journal of Chemistry，Organic Letters，Journal of Organic Chemistry，Advanced Synthesis & Catalysis发表论文多篇。
电子邮箱：duanxiyan@tju.edu.cn
二、教育和工作经历
2002.9 - 2006.6，河北大学，药学，学士
2006.9 - 2008.6，天津大学，药物化学，硕士
2009.9 - 2012.6，南开大学，化学生物学，博士
2016.11 - 2017.11, 威斯康星大学麦迪逊分校，药学院，访问学者；
2012.7 – 至今，河南科技大学 化学化工学院
三、主要研究方向
（1）药物化学 主要围绕天然产物中活性成分进行结构的改造和修饰，以期发现具有更高活性和代谢稳定性的天然产物衍生物；
（2）有机合成方法学 主要聚焦杂环化合物的合成，特别是具有生物活性的杂环结构x新颖合成方法学的研究。
四、代表性学术成果
1. Xiyan Duan*, Junqi Wang, Xiaoguang Huo, Zhuo Shen, Yahui Ding*. Discovery of novel fluorine-containing parthenolide analogues as potential antitumor agents. European Journal of Medicinal Chemistry. 2025, 286, 117283.
2. Yongping Bai, Junqi Wang, Weinan Li, Ning Liu, Kun Liu, Hui Li, Yihao Zhao, Xiyan Duan*, Yahui Ding*; Design, synthesis and bioactivity evaluation of parthenolide-chalcone hybrids as potential anti-lung cancer agents. Bioorganic Chemistry. 2025, 164, 108808.
3. Xiyan Duan*, Junqi Wang, Kun Liu, Fengjiao Du, Maoling He, Wenxin Li, Xinming Liu, Pu Liu* Copper-mediated divergent synthesis of halogenated 1-pyrrolines, 3-azabicyclo[3.1.0]hex-2-enes and α,α-dibromo imines from N-allyl enamines. Org. Chem. Front., 2025,12, 4012.
4. Xiyan Duan*, Junqi Wang, Hui Li, Fengjiao Du, Ran Chen, Weidong Lian and Meixin ShiTandem site-selective bromination and highly regioselective Heck reaction of N-allyl enaminones: chemodivergent synthesis of polysubstituted pyrroles and pyridines. Org. Chem. Front., 2024, 11, 5532.
5. Xiyan Duan*, Hui Li, Junqi Wang, Kun Liu, Meixin Shi, Weidong Lian, Ran Chen, Pu Liu* Chemodivergent Synthesis of Benzofurans and 2,3-Dihydrobenzofurans via Tandem Oxidative Annulation of Enaminones and Salicylaldehydes. Chin. J. Chem. 2024, 42, 1727.
6. Xiyan Duan*, Ning Liu, Ke Lv, Junqi Wang, Mingyue Li, Yanwei Zhang, Xiaoguang Huo, Shiqi Bao, Zhuo Shen, Xuemei Zhang. Synthesis and Anti-Inflammatory Activity of Ferulic Acid-Sesquiterpene Lactone Hybrids. Molecules 2024, 29, 936.
7. Xiyan Duan*, Junqi Wang, Wanting Qu, Hui Li, Fengjiao Du. Oxidative rearrangement of enaminones to α-keto amides in the presence of KI, TBHP and octanoic acid. Tetrahedron Lett. 2024, 142, 155105.
8. Xiyan Duan*, Xiaojing Liu, Xiaodan Cuan, Lin Wang, Kun Liu, Huiyun Zhou, Xue Chen, Huimin Li, Junqin Wang. Solvent-Controlled Synthesis of Thiocyanated Enaminones and 2‑Aminothiazoles from Enaminones, KSCN, and NBS. J. Org. Chem. 2019, 84, 12366.
9. Xiyan Duan*, Kun Yang, Jun Lu, et. al., Base-Mediated Cascade Substitution−Cyclization of 2H‑Azirines: Access to Highly Substituted Oxazoles. Org. Lett. 2017, 19, 3370.
10. Xiyan Duan*; Kun Yang, Jianwei Liu, et. al. An unexpected potassium iodide-promoted nucleophilic substitution reaction between 2-Acyloxy-2H-azirines and carboxylic acids. Adv. Synth. Catal. 2016, 358, 3161.
11. Jicheng Wu, Xiaolei Li, Xiaotian Qi, Xiyan Duan, Weston L. Cracraft, Ilia A. Guzei, Peng Liu,* Weiping Tang*, Site-Selective and Stereoselective O‑Alkylation of Glycosides by Rh(II)-Catalyzed Carbenoid Insertion. J. Am. Chem. Soc. 2019, 141, 19902.
